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Tetramethylguanidine CAS 80-70-6 TMG

TMG is a colorless to light yellow transparent liquid with strong alkaline (pKa≈13.6) and ammonia-like odor. Mainly used as catalyst for organic synthesis (e.g. polyurethane), deacidifier and DNA/RNA modification reagent, its high reactivity and low nucleophilicity are outstanding. It needs to be sealed and kept away from light, it is highly corrosive to skin/eyes, and requires strict protection for handling.
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  • 80-70-6

Tetramethylguanidine Basic information
Product Name: Tetramethylguanidine
CAS: 80-70-6
MF: C5H13N3
MW: 115.18
EINECS: 201-302-7
Mol File: 80-70-6.mol
Tetramethylguanidine Chemical Properties
Melting point -30 °C
Boiling point 162-163 °C (lit.)
density 0.916 g/mL at 20 °C (lit.)
vapor pressure 0.2 mm Hg ( 20 °C)
refractive index n20/D 1.469
Fp 140 °F
storage temp. Store below +30°C.
solubility Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka 15.20±0.70(Predicted)
form Liquid
color APHA: ≤150
PH 12.7 (10g/l, H2O, 25℃)
Relative polarity 5.5
Odor mild ammoniacal odor
explosive limit 1.0-7.5%(V)
Water Solubility miscible
Sensitive Air Sensitive
BRN 969608
Dielectric constant 23.1
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide. Air-sensitive.
InChIKey KYVBNYUBXIEUFW-UHFFFAOYSA-N
LogP -0.49 at 20℃
CAS DataBase Reference 80-70-6(CAS DataBase Reference)
NIST Chemistry Reference N,N,N',N'-Tetramethylguanidine(80-70-6)
EPA Substance Registry System Guanidine, N,N,N',N'-tetramethyl- (80-70-6)

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