Acetophenone CAS 98-86-2

Acetophenone, also known as acetophenone, has a boiling point (℃): 202.3, relative density (water = 1): 1.03 (20℃), relative vapor density (air = 1): 4.14. It is the simplest aromatic ketone, in which the aromatic nucleus (benzene ring) is directly connected to the carbonyl group. It exists in the essential oils of some plants in a free state. The pure product is a colorless crystal. Most of the commercial products are light yellow oily liquids. It has a hawthorn-like aroma. It is slightly soluble in water and easily soluble in a variety of organic solvents, and can evaporate with steam. Acetophenone molecular structure: the methyl C atom forms a bond with an sp3 hybrid orbital, and the benzene ring and the carbonyl C atom form a bond with an sp2 hybrid orbital. Acetophenone can undergo carbonyl addition reaction, α-active hydrogen reaction, and electrophilic substitution reaction on the benzene ring, mainly generating meta-position products.

Acetophenone can be prepared by reacting benzene with acetyl chloride, acetic anhydride or acetic acid under the catalysis of aluminum chloride. In addition, acetophenone is a by-product when ethylbenzene is catalytically oxidized to styrene. Acetophenone is mainly used as a raw material for pharmaceutical and other organic synthesis, and is also used to prepare spices. It is used to make soaps and cigarettes. It can also be used as a solvent for cellulose ethers, cellulose esters and resins, as well as a plasticizer for plastics. It has a hypnotic effect. Nowadays, acetophenone is mostly obtained as a byproduct of phenol and acetone oxidation of cumene. It can also be obtained by acetylation of benzene with acetyl chloride.