Food Grade 99.7% D-Aspartic acid CAS 1783-96-6

What is D-Aspartic acid (CAS 1783-96-6)? How does it work?

D-Aspartic acid, with the chemical formula C₄H₇NO₄, molecular weight 133.10, CAS number 1783-96-6, and PubChem CID 83887, is the D-enantiomer of aspartic acid (a mirror image of L-aspartic acid, which participates in protein synthesis). D-Aspartic acid is one of the two naturally occurring D-amino acids in mammals. It does not participate in routine protein synthesis and mainly exists in body tissues as a neuromodulator and metabolic regulator. In the food industry, this product is a compliant food-grade dietary supplement ingredient (PubChem classification), used only in functional foods, sports nutrition foods, dietary supplements, and other food-related end products. Common dosage forms include capsules, tablets, powders, and functional beverages. Therefore, its functional effects claims in food products should be considered "research-based and individualized."

Basic identification information : Chemical formula C4H7NO4 (HOOC-CH(NH2)-CH2-COOH); Molecular weight 133.10; CAS number 1783-96-6; PubChem CID 83887; IUPAC name (2R)-2-aminobutanedioic acid; InChIKey CKLJMWTZIZZHCS-UWTATZPHSA-N; Aliases: D-aspartic acid, D-aspartate, (R)-aspartic acid; Three-letter/single-letter amino acid code Asp/D.

Structurally and in manufacturing, D-aspartic acid is the chiral enantiomer of L-aspartic acid (with opposite α-carbon chiral center configurations), containing one amino group and two carboxyl groups. Industrially, it is produced from chemically synthesized racemic aspartic acid (DL-aspartic acid) via chiral resolution (preferably crystallization resolution or enzymatic kinetic resolution, such as aspartate racemicase or N-acetyltransferase resolution) or asymmetric synthesis. Food-grade products must meet the purity and optical purity (enantiomer excess ee value) requirements for dietary supplement raw materials, and are white crystalline powders.

Physically , food-grade D-aspartic acid is a white crystalline or crystalline powder, almost tasteless or slightly acidic; density approximately 1.51 g/cm³; melting point approximately 270℃ (decomposes); slightly soluble in water (solubility approximately 4 g/L at 25℃), readily soluble in dilute acids and alkalis, insoluble in ethanol and ether; specific rotation [α]D₂₀ approximately -25° (c=8, 6 mol/L hydrochloric acid, mirror image of the L-type +25°); isoelectric point (pI) approximately 2.77; non-hygroscopic and stable.

Chemically , D-aspartic acid is an acidic amino acid containing two carboxyl groups (pKa approximately 1.9, 3.6, 9.8): it exists as a negatively charged aspartate group at physiological pH; the amino and carboxyl groups can participate in peptide bond formation and complex with metal ions; its enantiomeric specificity allows it to be oxidized and deaminated by D-aspartate oxidase (DDO) (the L-form cannot); it is chemically stable and non-toxic.

What are all the uses of food-grade D-Aspartic acid (CAS 1783-96-6)?

1. Sports nutrition and dietary supplements (civilian health products, functional foods)

Application areas : functional dietary foods, sports nutrition, functional nutrients, health food formulation development, and contract manufacturing of health foods.

Corresponding products : D-Aspartic acid muscle-building powder, strength-enhancing compound supplement, functional conditioning dietary capsules, sports recovery beverage additives, endogenous metabolism regulating nutrients, and compound amino acid functional formula ingredients.

Why it works: D-Aspartic acid is an endogenous functional chiral amino acid that participates in the regulation of endocrine metabolism and energy metabolism in the human body. It can also help regulate hormone metabolism, relieve high-intensity exercise-induced fatigue and improve the body's exercise tolerance. D-form amino acids have unique metabolic pathways and physiological activities compared to normal L-type amino acids, and are suitable for daily functional conditioning in adults and performance-enhancing formulas for athletes. It has good solubility and compatibility, can be compounded with nutrients such as zinc, magnesium and vitamins, and can stably incorporate into various dietary formulas. It is one of the basic raw materials of sports nutrition and functional dietary supplements.

2. Livestock and aquaculture additives sector (livestock farming, feed industry)

Application areas : livestock and poultry breeding, aquaculture, special economic animal breeding, functional feed formulation, stress regulation in animal husbandry, and quality improvement of breeding livestock and poultry.

Corresponding products : feed-grade D-aspartic acid functional additives, livestock and poultry anti-stress feed additives, breeding performance improvement additives for poultry, aquatic growth-promoting compound amino acid additives, and feed conversion rate improvement premix raw materials.

Why it is good for this purpose: D-Aspartic acid has good biocompatibility and metabolic activity, and plays a good role in regulating the endocrine system and metabolic function of livestock, poultry and aquatic animals. It reduces stress caused by environmental changes and high-density farming, improves intestinal absorption, and greatly improves the digestibility and utilization of feed. And simultaneously it optimizes the reproductive metabolic state of breeding livestock and poultry, improves the reproductive performance and survival rate of larvae. Stable and heat resistant, suitable for industrial feed production processes. It is very safe, does not leave any residue and meets the criteria to be used as a green aquaculture additive.

3. Fine Chemicals and Chiral Synthesis (Fine Chemicals, Intermediate Synthesis)

Application areas : chiral fine chemicals, asymmetric organic synthesis, peptide synthesis, preparation of chiral intermediates, and research and mass production of high-end fine chemicals.

Corresponding products : chiral synthesis building block reagents, asymmetric synthesis chiral templates, high-purity peptide synthesis monomers, chiral resolving agent raw materials, fine chemical chiral intermediates, and special amino acid derivative synthesis raw materials.

Why it is suitable for this application :D-aspartic acid is a typical high-quality building block for chiral synthesis, since it has a single, stable chiral center with high optical purity and well-defined stereoselectivity. It has the dicarboxyl and amino active functional groups in a typical molecular framework, which has abundant reactive sites and can participate in organic reaction efficiently, such as acylation, esterification and condensation, constructing the skeletons of various chiral compounds accurately. Compared with racemic compounds, the single D configuration avoids stereoisomerization side reactions, which dramatically improves the purity and yield of chiral synthetic products. It has been widely used for the synthesis and preparation of high-end fine chemicals, specialty peptides and chiral functional materials.

4. Chiral analysis standards and reagents (analytical testing field)

Application areas : food testing, environmental monitoring, biological sample analysis, third-party testing laboratories, scientific research analysis, widely applicable to the entire process of qualitative and quantitative detection of chiral amino acids, enantiomeric purity verification, instrument calibration and experimental quality control.

Corresponding products : High-purity chiral analysis standard for D-aspartic acid, enantiomeric separation control standard for D/L aspartic acid, HPLC chiral column calibration standard, amino acid pre-column derivatization (OPA/NAC, Marfey reagent system) detection standard, special reagent for capillary electrophoresis (CE) chiral analysis, quality control samples for food amino acid configuration detection, chiral detection standard for biological metabolic samples, and special reference reagent for chiral chromatography method validation.

Why it is suitable for this application : D-aspartic acid possesses a single, stable chiral center with well-defined optical activity. Its standard specific rotation [α]20/D is approximately -24° to -25°, forming a complete mirror-image enantiomer structure with L-aspartic acid. Its optical purity can reach over 98%, with no significant interference from racemic impurities. Its physicochemical properties are stable, and its derivatization reactions are specific. It is suitable for pre-column derivatization-HPLC and HPLC-MS/MS. It can be used as a reference substance to establish standard curves, calibrate chiral chromatographic columns and the accuracy of detection instruments, and also as a positive control to verify the separation effect of D/L amino acid enantiomers. It effectively solves the problem of conventional detection being unable to distinguish the chiral configuration of amino acids, accurately achieving qualitative identification and precise quantification of D-aspartic acid in food and biological samples. This ensures the accuracy, repeatability, and reliability of data in chiral analysis experiments, making it a core reference reagent for amino acid chiral analysis and enantiomer purity quality control.

Summarize

D-Aspartic acid (C4H7NO4, CAS 1783-96-6) is a food grade chiral amino acid ingredient for sports nutrition conditioning, human function maintenance and metabolic fatigue relief. It is the only product with compliant food applications in the fields of sports nutrition and men's functional dietary supplements, with its triple food-grade core characteristics of "mildly regulating endocrine metabolism + endogenous neuromodulation and maintenance + sports fatigue enhancement," making it a mainstream functional ingredient in the current dietary supplement market. The food-grade product is a white crystalline powder, slightly soluble in water and soluble in dilute acids and alkalis. The melting point is about 270℃ (decomposes), the specific optical rotation is about -24° to -25°, and the isoelectric point is about 2.77. It has stable physicochemical properties, high food safety, strong compatibility, and can be conventionally formulated into capsules, tablets, powder, functional beverages and other food products.