Hydroxyapatite, also known as hydroxyapatite, is a natural mineralization of calcium apatite (Ca5(PO4)3(OH)). Its molecular formula is Ca5(PO4)3(OH), but it is often written as Ca10(PO4)6(OH)2 to indicate a crystal structure composed of two molecules. Hydroxyapatite is a pure hydroxide-containing endmember in apatite. OH- ions can be replaced by fluoride, chloride or carbonate ions to form fluoroapatite or chloroapatite. Hydroxyapatite, abbreviated as HAP, is the most widely used calcium phosphate crystalline phase. Calcium phosphate is the main mineral component of vertebrate bones and teeth, and among calcium phosphates, hydroxyapatite is the most thermodynamically stable crystalline phase of calcium phosphate in body fluids, most similar to the mineral part of human bones and teeth. The ratio of calcium to phosphorus in hydroxyapatite is affected by the synthesis method, and the ratio of calcium to phosphorus is not fixed, and its composition is also complex.
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