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Chinese name | manganese sulfate |
English name | Manganese sulfate / Manganese(II) sulfate |
Molecular formula | MnSO₄·H₂O (monohydrate – the most common form in food grade) |
molecular weight | 169.02 |
CAS number | 10034-96-5 (monohydrate) |
Appearance | Pale pink crystals or powder (trace amounts of moisture will make it appear pink); high-purity anhydrous form is nearly white. |
Solubility | It is readily soluble in water, and its aqueous solution is weakly acidic. |
manganese content | Approximately 32.5% (monohydrate, as Mn) |
smell | Slightly astringent, with a slightly metallic taste |
This is the most important application of food-grade manganese sulfate in human nutrition. Infant formula must mimic the mineral composition of breast milk, and although the manganese content in breast milk is extremely low (about 3~10 μg/L), it is crucial for the normal development of an infant's bones and nervous system.
In the "dry mixing" or "wet mixing" process at infant formula factories, manganese sulfate is weighed, dissolved, and mixed into tons of milk powder with microgram precision. This requires the raw materials to have the following characteristics:
Extremely high batch purity consistency—the manganese content of each batch of MnSO₄·H₂O must be stable (within ±1%), otherwise the actual manganese content in the infant formula will deviate from the formula standard;
Extremely low crystal form and particle size variation—in dry mixing processes, crystals that are too coarse may not be able to disperse evenly—one scoop of the same can of milk powder may contain manganese, while the next scoop may not;
Absolute safety guarantee against heavy metals – the damage to an infant's nervous system caused by lead and arsenic is irreversible.
For patients who are unable to eat normally due to illness and rely on enteral nutrition preparations for a long time—these preparations must contain a complete set of trace elements, including manganese. Manganese sulfate plays the most basic and controllable role as an inorganic manganese source in such products—it has good solubility, high stability in solution, and is economical, making it suitable for large-scale industrial production.
In sports drinks and meal replacement powders containing manganese, the Mn²⁺ provided by manganese sulfate is absorbed by the human body and enters the mitochondria to become the cofactor of Mn-SOD. Among the large number of free radicals generated during each high-intensity exercise, Mn-SOD is the first line of defense for mitochondria against oxidation.
Compared to other organic manganese sources (such as manganese gluconate), manganese sulfate has a disadvantage in this application: it may impart a very slight metallic astringent taste—but this astringency is completely masked in sports drinks containing large amounts of flavorings and sweeteners. Its advantage is its high manganese content and extremely low cost—the cost of the manganese source is almost negligible in products containing only 0.5–2 mg of manganese per serving.
In some countries, salt is used as a carrier for fortifying multiple trace elements—manganese sulfate is one of the manganese source options. Manganese sulfate can be used as a trace manganese fortifying ingredient in soy sauce, soup bases, and compound seasonings.
Manganese sulfate (food grade) is perhaps the food fortifier used in the smallest quantities, but for the most vulnerable population. In each can of infant formula, it's added in only a few tens of milligrams—but these few milligrams are far more significant than its weight:
Scene | What is it doing? |
Infant formula | Protecting the normal growth of cartilage and bone with a precision of micrograms per 100 milliliters. |
Prenatal Nutrition Tablets | Supports the development of the fetal skeletal system—the manganese in each tablet crosses the placenta and enters the baby's cartilage. |
Enteral nutrition formula | To prevent manganese deficiency in patients who are unable to eat normally—resulting in no joint pain and no brittle bones. |
Sports recovery drink | Entering the mitochondria to become Mn-SOD—clearing free radicals after each high-intensity training session. |
It is the most unassuming of the trace elements—lacking the red of iron, the white of zinc, and the massive quantities of calcium. It is a pale pink powder, almost invisible, undetectable, and unweighable in a whole can of baby formula—but when it is absent, a baby's bones will stagnate in a soft and invisible state.